Glutaraldehyde Modification of Recombinant Human Hemoglobin Alters Its Hemodynamic Properties
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چکیده
منابع مشابه
Glutaraldehyde modification of recombinant human hemoglobin alters its hemodynamic properties.
Many cell-free hemoglobin solutions designed as oxygen-carrying therapeutics produce a hypertensive effect in animals. The response is likely due to oxidation of nitric oxide by hemoglobin. Since the site of oxidation may lie outside the vascular compartment, we tested the hypothesis that polymerization of hemoglobin, rHb1.1, by glutaraldehyde would attenuate the hypertensive response. Two prod...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.4.2583